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What's your favorite kind of prep chromatography system?
From the inbox, a request from a longtime friend of the blog who needs to choose between two kinds of flash chromatography systems (edited for privacy and clarity):
Please do you know any colleagues who can share their impression on recent LC flash silica models from Biotage - and from Buchi?
The first option that they are pitching us is a Biotage Isolera Prime. So this is their economy model with 1 wavelength UV detector and single rack fraction collector, for $15,200.
The second option is slightly used Buchi Reveleris X2-UV, which is a mid-range model, with dual wavelength UV detector and two rack fraction collector, and supposedly better pumps, for $21,600.
Personally, I would feel lot more comfortable with Teledyne-ISCO but I cannot choose it. I have had unpleasant experience with clunky Biotage models a very long time ago so I am biased but it is probably not relevant. The Buchi system looks similar to Combiflash. But I have seen that Buchi also sometimes does not make great products (for example their teflon vacuum pumps and automated vacuum control boxes, designed as knock-off of KNF pumps, used to be a major weakness of the Buchi rotovaps)I haven't loved the Revelaris systems that I have seen/worked with, but I'm probably biased. The Biotage systems that I worked with a long time ago were just fine. Readers, your thoughts?
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